Tell all of your health care providers that you take this medicine (simvastatin tablets). Simvastatin side effects (in more detail). It comes in two forms: a tablet and a suspension. Do not breast-feed while you take this medicine (simvastatin tablets). If you are allergic to this medicine (simvastatin tablets); any part of this medicine (simvastatin tablets); or any other drugs, foods, or substances. Patient Counselling This drug may cause dizziness, if affected, do not drive or operate machinery. Some drugs may have another patient information leaflet. Simvastatin, a prodrug, is converted to its active metabolite simvastatin acid (SVA), which is a substrate of the organic anion transporter protein OATP1B1. You may need to take simvastatin on a long-term basis for the treatment of high cholesterol. Simvastatin belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins.". Simvastatin is metabolised through the CYP3A4 pathway. Do not store in a bathroom. Both forms are taken by mouth. Call your doctor right away if you have muscle Liver problems have happened with drugs like this one. Do not use more than 20 mg per day of simvastatin together with amiodarone (Cordarone®), amlodipine (Norvasc®), lomitapide (Juxtapid™), or ranolazine (Ranexa®). Talk with the doctor. what signs you had. Tell your doctor about the allergy and Do not use if you are pregnant or planning to become pregnant. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Simvastatin (Zocor) is a cholesterol-lowering medication that blocks the production of cholesterol. There may be drug take-back programs in your area. Taking too much of this medication may cause serious or life-threatening side effects. Hypercholesterolemia. Avoid drinking alcohol. Also call your doctor at once if you have: signs of a kidney problem - little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath; or. Are Statin Side Effects 'All in Your Head'? If you are Chinese, talk with your doctor. The breakdown of muscle fibres resulting in the release of muscle fibre contents (myoglobin) into the bloodstream. Find out what health conditions may be a health risk when taken with Simvastatin Oral Sometimes, this has been deadly. Do not consume grapefruit products while taking this medication. Your doctor may occasionally change your dose to make sure you get the best results. Simvastatin 10 mg tablets can be sold to the public to reduce risk of first coronary event in individuals at moderate risk of coronary heart disease (approx. Taking too much of this medication may cause serious or life-threatening side effects. Keep taking this medicine (simvastatin tablets) as you have been told by your doctor or other health care provider, even if you feel well. (2.2) • Patients who are currently tolerating the 80-mg dose of ZOCOR who need to be initiated on an interacting drug that is contraindicated or is associated with a dose cap for simvastatin should be switched to Follow the diet and workout plan that your doctor told you about. Drinking too much alcohol may raise your chance of liver disease. Description: Simvastatin inhibits the conversion of HMG-CoA to mevalonic acid by blocking the enzyme HMG-CoA reductase, an early and rate limiting step in the biosynthesis of cholesterol.Ezetimibe localises at the brush border of the small intestine where it inhibits the absorption of cholesterol, decreasing the delivery of intestinal cholesterol to the liver. Patients with Child-Pugh C have a high short-term liver mortality, which is unlikely to be modified by statins. help if any of these side effects or any other side effects bother you or do not go away: These are not all of the side effects that may occur. Are Statin Side Effects 'All in Your Head'? Call your doctor or get medical Skip the missed dose if it is almost time for your next scheduled dose. Your doctor may need to change your treatment plan if you use certain antibiotics or antifungal medicines, hepatitis C medication, heart medication, or medicines to treat HIV/AIDS. Simvastatin belongs to a group of medicines called statins.. It may be given to you for other reasons. Generic Name: simvastatin (SIM va sta tin) This trial was designed to compare the efficacy of atorvastatin 10 mg with simvastatin 10 mg and 20 mg, the latter dose being commonly used in some countries. 10 mg/10 mg/day-10 mg/40 mg/day PO qHS. If you have high blood sugar (diabetes), you will need to watch your blood sugar closely. Simvastatin side effects (in more detail). Not all possible interactions are listed here. Tell your Check with your This medicine may cause harm to the unborn baby if you take it while you are pregnant. Simvastatin dosage information (in more detail). Simvastatin is also used to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol (''bad cholesterol'') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol (''good cholesterol'') in th… In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. We comply with the HONcode standard for trustworthy health information -, Simvastatin pregnancy and breastfeeding warnings. Use effective birth control to avoid pregnancy while you are taking this medicine. When used together with higher doses of simvastatin, these medicines may increase your risk of muscle injury and could result in kidney problems. Detailed Simvastatin dosage information for adults and children. Throw away unused or expired drugs. In patients taking simvastatin 80 mg for whom an interacting agent is needed, a lower dose of simvastatin or an alternative statin-based regimen with less potential for drug-drug interactions should be used (see below Measures to reduce the risk of myopathy caused by medicinal product interactions and sections 4.2, 4.3, and 4.5). You could have more side effects. Studies have found that after 10 days of amlodipine (10 mg), the AUC0-24h of simvastatin and simvastatic acid following a singl… Simvastatin is a substrate for CYP3A4 and the drug transporter organic anion transporting polypeptide (OATP1B1); protease inhibitors are CYP3A4 and OATP inhibitors. Follow all instructions closely. It is used along with exercise, diet, and weight loss to decrease elevated lipid levels. The recommended dose range of simvastatin is 10 mg to 40 mg, and it is administered once daily in the evening with or without food. Indication : 10–15 % risk of major event in 10 years), max. Never take this medicine in larger amounts, or for longer than prescribed. Version: 18.01. If you take simvastatin more than once daily, take it with meals. Includes dosages for Prevention of Cardiovascular Disease, Cardiovascular Risk Reduction, Heterozygous Familial Hypercholesterolemia and more; plus renal, liver and dialysis adjustments. Lovastatin; Niacin: (Major) There is no clear indication for routine use of niacin in combination with simvastatin. Grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effects. with your doctor, nurse, pharmacist, or other health care provider. any drug without checking with your doctor. While taking this medication should follow a proper diet to lower cholesterol. This is not a list of all drugs or health problems that interact with this medicine (simvastatin tablets). Simvastatin is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood). Common side effects include constipation, headaches, and nausea. Lovastatin; Niacin: (Major) There is no clear indication for routine use of niacin in combination with simvastatin. Call your doctor for medical advice about side effects. Simvastatin is usually taken at bedtime or with an evening meal. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Cardiology 77 (1990): 58-65. Do not start, stop, or change the dose of Coadministration of niacin (≥1 g) in patients of Chinese descent. Do not take 2 doses at the same time or extra doses. Simvastatin is a prodrug and is hydrolyzed to its active -hydroxyacid form, simvastatin acid, after administration. While using simvastatin, you may need frequent blood tests at your doctor's office. This includes your doctors, nurses, pharmacists, and dentists. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others.
2020 indication of simvastatin